Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion in the Posterior Circulation

Prof. Raul G. Nogueira

Study started April 2023, Ongoing

ClinicalTrials.gov Identifier: NCT05897554


The IAT-TOP trial is a government-funded, prospective, multicenter, randomized controlled trial. Patients will be randomized (1:1) to intra-arterial rt-PA group or without intra-arterial rt-PA group. Primary outcome is the rate of modified Rankin Scale score of 0-2 within 90 days after randomization. The IAT-TOP trial will be conducted in 34 sites in China.


Intra-arterial thrombolysisAlteplaseLarge vessel occlusionMechanical thrombectomyEndovascular treatment

Relevant article:

Adusumilli G, Kobeissi H, et al. Endovascular thrombectomy after acute ischemic stroke of the basilar artery: a meta-analysis of four randomized controlled trials. J Neurointerv Surg. 2023 Dec 21;15(e3):e446-e451. doi: 10.1136/jnis-2022-019776. PMID: 36597942.

Renú A, Millán M, et al. CHOICE Investigators. Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial. JAMA. 2022 Mar 1;327(9):826-835. doi: 10.1001/jama.2022.1645. PMID: 35143603; PMCID: PMC8832304.

Prof. Wenhuo Chen
Prof. Liqun Jiao
Cangzhou Central HospitalProf.Liu Yongchang
Changzhou First People's HospitalProf.Pengya
Zhangzhou Hospital, Fujian ProvinceProf.Chen Wentuo
Gansu Provincial Hospital of Traditional Chinese MedicineProf.Cao Hua
Ganzhou People's HospitalProf.Zeng Guoyong
Gaomi People's HospitalProf.Wu Shaoguang
The First Affiliated Hospital of Harbin Medical UniversityProf.Zhang Guang
Hangzhou First People's HospitalProf.Yin Congguo
Jinan Central HospitalProf.Zhao Yanxin
Jiamusi Central HospitalProf.Xu Lihua
Lishui Central HospitalProf.CAI Xueli
Liaocheng Second People's HospitalProf.Chang Wansheng
Liaocheng Third People's HospitalProf.Song Cunfeng
Liaocheng Brain HospitalProf.Zhang Liyong
Linyi City People's HospitalProf.Han Hongxing
Luoyang Central HospitalProf.Wei Liping
The First Affiliated Hospital of Nanchang UniversityProf.Fang Pu
Jiangsu Provincial People's HospitalProf.Liu Sheng
Nanning Second People's HospitalProf.Li Tong
Nanyang South Stone HospitalProf.Zhu Shuai
Nanyang City Central HospitalProf.Liu Yifeng
The Second Affiliated Hospital of Shandong First Medical UniversityProf.Zheng Wei
First Hospital of Shanxi Medical UniversityProf.Zhang Jin
Shenyang Brain HospitalProf.Sui Yi
Xuanwu Hospital, Capital Medical UniversityProf.Focal group
Songyuan Jilin Oilfield HospitalProf.Ju Dongsheng
Taizhou First People's HospitalProf.Xu Chenghua
Tianjin Huanhu HospitalProf.Ma Lin
Wuhan First HospitalProf.Liu Wenhua
Wuhan Central HospitalProf.Jing Ping
The First Affiliated Hospital of Xi 'an Jiaotong UniversityProf.Yu Jia
Affiliated Hospital of Southwest Medical UniversityProf.Li Jinglun
Xiangtan Central HospitalProf.Yuan Guangxiong
Taizhou Hospital of Zhejiang ProvinceProf.Wang En
Heze Municipal HospitalProf.Li Kai
The Second Affiliated Hospital of Xi 'an Jiaotong UniversityProf.Zhang Guilian
Shanxi Cardiovascular Disease HospitalProf.Cheng Tao

Name of hospital
(In no particular order and in alphabetical order)
Research trends
June 1st
Complete Clinicaltrial Registration
July 4th
Group leader unit through ethics
July 18th
National platform system filing
July 27th
First Branch Center Passed Ethical Review
August 11th
First entry

Enrolled Cases

The number of enrolled cases is counted until April 21, 2024

+8615633140085(Site Manager:Dr.Shengyan Cui)



Xuanwu Hospital, Capital Medical University

45 Chang Chun Street

Xicheng District, Beijing, China



wangtao_dr@sina.com  (Team Manager Dr.Wang Tao)


Cerebral Recanalization Center CHINA-INI(@sss405084186525)