Extracranial-intracranial Bypass Surgery Versus Medical Treatment Alone for Symptomatic Chronic Middle Cerebral Artery Occlusion

Prof. Yuxiang Gu
Prof. Colin P. Derdeyn

Study started April 2023, Ongoing Identifier: NCT05899582 The CMOSS-2 trial is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit symptomatic chronic occlusion of the middle cerebral artery in patients with severe hemodynamic insufficiency. Only high-volume center with a proven track record will be included. Patients will be randomized (1:1) to best medical treatment alone or medical treatment plus bypass surgery. Primary outcome is ischemic stroke in the territory of the target artery within 24 months after randomization. The CMOSS-2 trial will be conducted in 13 sites in China. Keywords: Middle cerebral artery occlusion, stroke,TIA Relevant article: Ma Y, Wang T, et al. CMOSS Investigators. Extracranial-Intracranial Bypass and Risk of Stroke and Death in Patients With Symptomatic Artery Occlusion: The CMOSS Randomized Clinical Trial. JAMA. 2023 Aug 22;330(8):704-714. doi: 10.1001/jama.2023.13390. PMID: 37606672; PMCID: PMC10445185.

Gao P, Wang T, et aal. CASSISS Trial Investigators. Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial. JAMA. 2022 Aug 9;328(6):534-542. doi: 10.1001/jama.2022.12000IF: 120.7 Q1 . PMID: 35943472; PMCID: PMC9364128.

Powers WJ, Clarke WR, et al. COSS Investigators. Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. JAMA. 2011 Nov 9;306(18):1983-92. doi: 10.1001/jama.2011.1610. Erratum in: JAMA. 2011 Dec 28;306(24):2672. Obviagele, Bruce [corrected to Ovbiagele, Bruce]. PMID: 22068990; PMCID: PMC3601825.

Prof. Yan Ma
Prof. Liqun Jiao
Huashan Hospital affiliated to Fudan UniversityProf.Gu Yuxiang
The First Affiliated Hospital of Harbin Medical UniversityProf.Zheng Bingjie
Liaocheng Brain HospitalProf.Zhang Liyong
Nanfang Hospital, Southern Medical UniversityProf.Wang Gang
Nanjing Gulou HospitalProf.Hang Chunhua
The First Affiliated Hospital of Ningbo UniversityProf.Lin Jinghui
Shandong University Qilu HospitalProf.Zhao Peng
Beijing Tiantan Hospital, Capital Medical UniversityProf.Wang Rong
Xuanwu Hospital, Capital Medical UniversityProf.Ma Yan
West China Hospital of Sichuan UniversityProf.Liu Yi
The First Affiliated Hospital of Soochow UniversityProf.Huang Yabo
Tianjin Huanhu HospitalProf.Tong Xiaoguang
Zhongnan Hospital of Wuhan UniversityProf.Chen Jincao/Prof.Zhang Jianjian

Name of hospital
(In no particular order and in alphabetical order)

Research trends

June 1st
Complete Clinicaltrial Registration
July 4th
Group leader unit through ethics
July 18th
National platform system filing
August 1st
First Branch Center Passed Ethical Review
September 15th
First entry

Enrolled Cases

The number of enrolled cases is counted until April 21, 2024
Extracranial-intracranial bypass surgery for symptomatic middle cerebral artery occlusion study-2 Trial initiated.

+8615633140085(Site Manager:Dr.Shengyan Cui)



Xuanwu Hospital, Capital Medical University

45 Chang Chun Street

Xicheng District, Beijing, China

Email:  (Team Manager Dr.Wang Tao)


Cerebral Recanalization Center CHINA-INI(@sss405084186525)